Endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN) is up-regulated
in the neointima of remodeling arteries and modulates vascular smooth muscle cell (VSMC)
growth. Platelet-derived growth factor (PDGF) is the prototypic growth factor for VSMCs and
plays a key role in vascular remodeling. Here, we sought to further define ESDN function in
primary human VSMCs. ESDN down-regulation by RNA interference significantly enhanced
PDGF-induced VSMC DNA synthesis and migration. This was associated with increased …