[HTML][HTML] Hepatocyte growth factor regulates angiotensin converting enzyme expression
RM Day, G Thiel, J Lum, RD Chévere, Y Yang… - Journal of Biological …, 2004 - ASBMB
Hepatocyte growth factor (HGF) is a mitogen, morphogen, and motogen that functions in
tissue healing and acts as an anti-fibrotic factor. The mechanism for this is not well
understood. Recent studies implicate somatic angiotensin-converting enzyme (ACE) in
fibrosis. We examined the effects of HGF on ACE expression in bovine pulmonary artery
endothelial cells (BPAEC). Short term treatment of BPAEC with HGF transiently increased
both ACE mRNA (3 h) and activity (24 h), as determined by ACE protease assays and …
tissue healing and acts as an anti-fibrotic factor. The mechanism for this is not well
understood. Recent studies implicate somatic angiotensin-converting enzyme (ACE) in
fibrosis. We examined the effects of HGF on ACE expression in bovine pulmonary artery
endothelial cells (BPAEC). Short term treatment of BPAEC with HGF transiently increased
both ACE mRNA (3 h) and activity (24 h), as determined by ACE protease assays and …