[PDF][PDF] TOR, a central controller of cell growth
T Schmelzle, MN Hall - Cell, 2000 - cell.com
T Schmelzle, MN Hall
Cell, 2000•cell.comCell growth (increase in cell mass) and cell proliferation (increase in cell number) are
distinct yet coupled processes that go hand-in-hand to give rise to an organ, organism, or
tumor. Cyclin-dependent kinase (s) is the central regulator of cell proliferation. Is there an
equivalent regulator for cell growth? Recent findings reveal that the target of rapamycin TOR
controls an unusually abundant and diverse set of readouts all of which are important for cell
growth, suggesting that this conserved kinase is such a central regulator. Background In the …
distinct yet coupled processes that go hand-in-hand to give rise to an organ, organism, or
tumor. Cyclin-dependent kinase (s) is the central regulator of cell proliferation. Is there an
equivalent regulator for cell growth? Recent findings reveal that the target of rapamycin TOR
controls an unusually abundant and diverse set of readouts all of which are important for cell
growth, suggesting that this conserved kinase is such a central regulator. Background In the …
Summary
Cell growth (increase in cell mass) and cell proliferation (increase in cell number) are distinct yet coupled processes that go hand-in-hand to give rise to an organ, organism, or tumor. Cyclin-dependent kinase (s) is the central regulator of cell proliferation. Is there an equivalent regulator for cell growth? Recent findings reveal that the target of rapamycin TOR controls an unusually abundant and diverse set of readouts all of which are important for cell growth, suggesting that this conserved kinase is such a central regulator.
Background
In the late 1960s, Lee Hartwell isolated approximately 400 temperature-sensitive yeast mutants which he then characterized for macromolecular synthesis (protein and RNA synthesis), cell division, and cell morphology (
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