[HTML][HTML] Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress
XD Liu, S Ko, Y Xu, EA Fattah, Q Xiang… - Journal of Biological …, 2012 - ASBMB
Failure to maintain protein homeostasis (proteostasis) leads to accumulation of unfolded
proteins and contributes to the pathogenesis of many human diseases. Accumulation of
unfolded proteins in the endoplasmic reticulum (ER) elicits unfolded protein response (UPR)
that serves to attenuate protein translation, and increase protein refolding or degradation. In
contrast to UPR in the ER, the regulatory molecules operative in cytosolic responses and
their potential relation to ER stress are not well elucidated. Aggresome-like induced …
proteins and contributes to the pathogenesis of many human diseases. Accumulation of
unfolded proteins in the endoplasmic reticulum (ER) elicits unfolded protein response (UPR)
that serves to attenuate protein translation, and increase protein refolding or degradation. In
contrast to UPR in the ER, the regulatory molecules operative in cytosolic responses and
their potential relation to ER stress are not well elucidated. Aggresome-like induced …