A double-blind clinical trial in weight control: use of fenfluramine and phentermine alone and in combination
M Weintraub, JD Hasday, AI Mushlin… - Archives of Internal …, 1984 - jamanetwork.com
• We performed a double-blind, controlled clinical trial comparing phentermine resin (30 mg
in the morning), fenfluramine hydrochloride (20 mg three times a day), and a combination of
phentermine resin (15 mg in the morning) and fenfluramine hydrochloride (30 mg before the
evening meal), and placebo. We combined low doses of the two drugs to maintain efficacy
while diminishing adverse effects. Eighty-one people with simple obesity (130% to 180% of
ideal body weight) participated. Individualized diets were prescribed and discussed again …
in the morning), fenfluramine hydrochloride (20 mg three times a day), and a combination of
phentermine resin (15 mg in the morning) and fenfluramine hydrochloride (30 mg before the
evening meal), and placebo. We combined low doses of the two drugs to maintain efficacy
while diminishing adverse effects. Eighty-one people with simple obesity (130% to 180% of
ideal body weight) participated. Individualized diets were prescribed and discussed again …
