[HTML][HTML] Nuclear targeting of transforming growth factor-β-activated Smad complexes
HB Chen, JG Rud, K Lin, L Xu - Journal of Biological Chemistry, 2005 - ASBMB
Upon stimulation by the transforming growth factor β (TGF-β), Smad2 and Smad3 are
phosphorylated at their C termini and assemble into stable heteromeric complexes with
Smad4. These complexes are the functional entities that translocate into the nucleus and
regulate the expression of TGF-β target genes. Here we report that the TGF-β-activated
phospho-Smad3/Smad4 complex utilizes an importin-independent mechanism for nuclear
import and engages different nucleoporins for nuclear import compared with the monomeric …
phosphorylated at their C termini and assemble into stable heteromeric complexes with
Smad4. These complexes are the functional entities that translocate into the nucleus and
regulate the expression of TGF-β target genes. Here we report that the TGF-β-activated
phospho-Smad3/Smad4 complex utilizes an importin-independent mechanism for nuclear
import and engages different nucleoporins for nuclear import compared with the monomeric …