[HTML][HTML] Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element: degradation of Nrf2 by …
T Nguyen, PJ Sherratt, HC Huang, CS Yang… - Journal of Biological …, 2003 - ASBMB
Nrf2 (NF-E2-related factor 2) is a central transcription factor involved in the transcriptional
activation of many genes encoding phase II drug-metabolizing enzymes via the antioxidant
response element. Nrf2 has previously been found to undergo nuclear translocation by a
phosphorylation-dependent mechanism mediated by protein kinase C in HepG2 cells
treated withtert-butylhydroquinone, β-naphthoflavone, or 12-O-tetradecanoylphorbol-13-
acetate. In the present report, we have found that the levels of Nrf2 were increased in cells …
activation of many genes encoding phase II drug-metabolizing enzymes via the antioxidant
response element. Nrf2 has previously been found to undergo nuclear translocation by a
phosphorylation-dependent mechanism mediated by protein kinase C in HepG2 cells
treated withtert-butylhydroquinone, β-naphthoflavone, or 12-O-tetradecanoylphorbol-13-
acetate. In the present report, we have found that the levels of Nrf2 were increased in cells …