Co-expression of MAP-2 and GFAP in cells developing from rat EGF responsive precursor cells

AE Rosser, P Tyers, M Ter Borg, SB Dunnett… - Developmental brain …, 1997 - Elsevier
In this study we have performed a detailed analysis of EGF-responsive precursors as they
develop into neurons and astrocytes using antibodies to nestin, microtubule-associated
protein 2 (MAP-2c and MAP-2ab) and glial fibriallary acidic protein (GFAP). Surprisingly, at
early time points, most GFAP-positive cells also stained for MAP-2c, and we postulate that
this may be a normal stage of astroglial development. At 7 days most of the cells had
developed into astrocytes and MAP-2ab-positive cells only represented 5% of the total …