Renal ischemia/reperfusion (I/R) is a common cause of acute renal failure (ARF). Ischemic
ARF is associated with tubulointerstitial inflammation, and studies using animal models have
demonstrated that the inflammatory response to I/R exacerbates the resultant renal injury.
Ischemic ARF involves complement activation, the generation of cytokines and chemokines
within the kidney, and infiltration of the kidney by leukocytes. Recent work has revealed
some of the events and signals that trigger the inflammatory response to aseptic, hypoxic …