[HTML][HTML] Anti-complement component C5 mAb synergizes with CTLA4Ig to inhibit alloreactive T cells and prolong cardiac allograft survival in mice
H Raedler, MB Vieyra, S Leisman, P Lakhani… - American Journal of …, 2011 - Elsevier
While activation of serum complement mediates antibody-initiated vascular allograft injury,
increasing evidence indicates that complement also functions as a modulator of alloreactive
T cells. We tested whether blockade of complement activation at the C5 convertase step
affects T cell-mediated cardiac allograft rejection in mice. The anti-C5 mAb BB5. 1, which
prevents the formation of C5a and C5b, synergized with subtherapeutic doses of CTLA4Ig to
significantly prolong the survival of C57BL/6 heart grafts that were transplanted into naive …
increasing evidence indicates that complement also functions as a modulator of alloreactive
T cells. We tested whether blockade of complement activation at the C5 convertase step
affects T cell-mediated cardiac allograft rejection in mice. The anti-C5 mAb BB5. 1, which
prevents the formation of C5a and C5b, synergized with subtherapeutic doses of CTLA4Ig to
significantly prolong the survival of C57BL/6 heart grafts that were transplanted into naive …