Clinical relevance of pretransplant anti-HLA donor-specific antibodies: does C1q-fixation matter?
M Crespo, A Torio, V Mas, D Redondo… - Transplant …, 2013 - Elsevier
Anti-HLA donor-specific antibodies (DSA) identified by single antigen bead array (SAB) are
questioned for their excess in sensitivity and lack of event prediction after transplantation.
Population and methods We retrospectively evaluated specific types of preformed DSA
(class I, class II or C1q-fixing) and their impact on graft survival. Kidney transplantations
performed across negative CDC-crossmatch were included (n= 355). Anti-HLA antibodies
were tested using SAB to identify DSA and their capacity to fix C1q. Results Twenty-eight …
questioned for their excess in sensitivity and lack of event prediction after transplantation.
Population and methods We retrospectively evaluated specific types of preformed DSA
(class I, class II or C1q-fixing) and their impact on graft survival. Kidney transplantations
performed across negative CDC-crossmatch were included (n= 355). Anti-HLA antibodies
were tested using SAB to identify DSA and their capacity to fix C1q. Results Twenty-eight …