[HTML][HTML] Epac-mediated activation of phospholipase Cɛ plays a critical role in β-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac …
EA Oestreich, H Wang, S Malik… - Journal of biological …, 2007 - ASBMB
Recently we demonstrated that PLCɛ plays an important role in β-adrenergic receptor (βAR)
stimulation of Ca 2+-induced Ca 2+ release (CICR) in cardiac myocytes. Here we have
reported for the first time that a pathway downstream of βAR involving the cAMP-dependent
Rap GTP exchange factor, Epac, and PLCɛ regulates CICR in cardiac myocytes. To
demonstrate a role for Epac in the stimulation of CICR, cardiac myocytes were treated with
an Epac-selective cAMP analog, 8-4-(chlorophenylthio)-2′-O-methyladenosine-3′, 5 …
stimulation of Ca 2+-induced Ca 2+ release (CICR) in cardiac myocytes. Here we have
reported for the first time that a pathway downstream of βAR involving the cAMP-dependent
Rap GTP exchange factor, Epac, and PLCɛ regulates CICR in cardiac myocytes. To
demonstrate a role for Epac in the stimulation of CICR, cardiac myocytes were treated with
an Epac-selective cAMP analog, 8-4-(chlorophenylthio)-2′-O-methyladenosine-3′, 5 …