The use of mobilized peripheral blood stem cells (PBSCs) has largely replaced the use of
bone marrow as a source of stem cells for both allogeneic and autologous stem cell
transplantation. G-CSF with or without chemotherapy is the most commonly used regimen
for stem cell mobilization. Some donors or patients, especially the heavily pretreated
patients, fail to mobilize the targeted number of stem cells with this regimen. A better
understanding of the mechanisms involved in hematopoietic stem cell (HSC) trafficking …