A cluster of microvillous inclusion disease in the Navajo population
The Journal of pediatrics, 1999•Elsevier
We report 4 unrelated patients with characteristic microscopic findings of microvillous
inclusion disease (MID) with early-onset phenotype. All 4 patients came from the Navajo
reservation in northern Arizona. A literature search revealed a fifth unrelated Navajo child
with MID. The unusually high incidence in this population indicates that a founder effect
might be responsible for an increased frequency of this rare genetic disorder in the Navajo. It
is recommended that all Navajo infants presenting with severe diarrhea during early infancy …
inclusion disease (MID) with early-onset phenotype. All 4 patients came from the Navajo
reservation in northern Arizona. A literature search revealed a fifth unrelated Navajo child
with MID. The unusually high incidence in this population indicates that a founder effect
might be responsible for an increased frequency of this rare genetic disorder in the Navajo. It
is recommended that all Navajo infants presenting with severe diarrhea during early infancy …
We report 4 unrelated patients with characteristic microscopic findings of microvillous inclusion disease (MID) with early-onset phenotype. All 4 patients came from the Navajo reservation in northern Arizona. A literature search revealed a fifth unrelated Navajo child with MID. The unusually high incidence in this population indicates that a founder effect might be responsible for an increased frequency of this rare genetic disorder in the Navajo. It is recommended that all Navajo infants presenting with severe diarrhea during early infancy undergo investigation for MID. (J Pediatr 1999;134:103-6)
Elsevier