Impact of adjuvant inhibition of vascular endothelial growth factor receptor tyrosine kinases on tumor growth delay and local tumor control after fractionated irradiation …
PURPOSE: Previous experiments have shown that adjuvant inhibition of the vascular
endothelial growth factor receptor after fractionated irradiation prolonged tumor growth delay
and may also improve local tumor control. To test the latter hypothesis, local tumor control
experiments were performed. METHODS AND MATERIALS: Human FaDu and UT-SCC-14
squamous cell carcinomas were studied in nude mice. The vascular endothelial growth
factor receptor tyrosine kinase inhibitor PTK787/ZK222584 (50 mg/kg body weight bid) was …
endothelial growth factor receptor after fractionated irradiation prolonged tumor growth delay
and may also improve local tumor control. To test the latter hypothesis, local tumor control
experiments were performed. METHODS AND MATERIALS: Human FaDu and UT-SCC-14
squamous cell carcinomas were studied in nude mice. The vascular endothelial growth
factor receptor tyrosine kinase inhibitor PTK787/ZK222584 (50 mg/kg body weight bid) was …