Glial-derived neurotrophic factor (GDNF) prevents ethanol-induced apoptosis and JUN kinase phosphorylation
RE McAlhany Jr, JR West, RC Miranda - Developmental Brain Research, 2000 - Elsevier
Ethanol exposure during neural development leads to substantial neuronal loss in multiple
brain regions. Our previous research indicated that exogenous glial-derived neurotrophic
factor (GDNF) attenuated ethanol-induced cerebellar Purkinje cell loss. Additionally, ethanol
decreased GDNF release suggesting that ethanol disrupts GDNF-signaling pathways. The
present experiments utilized a homogeneous GDNF-responsive neuroblastoma cell line (SK-
N-SH) to test the hypothesis that exogenous GDNF could attenuate ethanol-induced cell …
brain regions. Our previous research indicated that exogenous glial-derived neurotrophic
factor (GDNF) attenuated ethanol-induced cerebellar Purkinje cell loss. Additionally, ethanol
decreased GDNF release suggesting that ethanol disrupts GDNF-signaling pathways. The
present experiments utilized a homogeneous GDNF-responsive neuroblastoma cell line (SK-
N-SH) to test the hypothesis that exogenous GDNF could attenuate ethanol-induced cell …