The Wnt/β-catenin pathway controls developmental processes and homeostasis; however,
abnormal activation of this pathway has been linked to several human diseases. Recent
reports have demonstrated regulation of platelet function by canonical and non-canonical
Wnt signalling. Platelet aggregation plays a crucial role in haemostasis and thrombosis.
Here we report for the first time that, induction of sustained aggregation of platelets by a
strong agonist in the presence of calcium was associated with nearly complete proteolysis of …