SOX2 is a high-mobility group box embryonic stem cell transcription factor that is expressed
in the developing foregut and normal gastric epithelium and is downregulated in intestinal
metaplasia of the stomach and esophagus. In addition, SOX2 colocalizes with p63 in the
basal layer and plays a critical role in the maintenance of the stratified squamous epithelium
of the esophagus. SOX2 expression in squamous cell carcinomas of the gastrointestinal
tract has not been previously evaluated. The purpose of this study was to determine whether …