[HTML][HTML] The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage
E Pohler, AL Craig, J Cotton, L Lawrie, JF Dillon… - Molecular & Cellular …, 2004 - ASBMB
The esophageal epithelium is subject to damage from bile acid reflux that promotes normal
tissue injury resulting in the development of Barrett's epithelium. There is a selection
pressure for mutating p53 in this preneoplastic epithelium, thus identifying a physiologically
relevant model for discovering novel regulators of the p53 pathway. Proteomic technologies
were used to identify such p53 regulatory factors by identifying proteins that were
overexpressed in Barrett's epithelium. A very abundant polypeptide selectively expressed in …
tissue injury resulting in the development of Barrett's epithelium. There is a selection
pressure for mutating p53 in this preneoplastic epithelium, thus identifying a physiologically
relevant model for discovering novel regulators of the p53 pathway. Proteomic technologies
were used to identify such p53 regulatory factors by identifying proteins that were
overexpressed in Barrett's epithelium. A very abundant polypeptide selectively expressed in …