Fibroblast growth factor 21 is induced by endoplasmic reticulum stress
Increased hepatic expression is held responsible for elevated serum levels of fibroblast
growth factor 21 (FGF21) in non-alcoholic fatty liver disease (NAFLD) but the underlying
molecular mechanism is unclear. In the present study we tested the postulate that the
metabolic hormone FGF21 is regulated by endoplasmic reticulum (ER) stress, a condition
that is observed in a number of diseases including NAFLD and results in activation of an
adaptive response known as the unfolded protein response (UPR). ER stress stimuli were …
growth factor 21 (FGF21) in non-alcoholic fatty liver disease (NAFLD) but the underlying
molecular mechanism is unclear. In the present study we tested the postulate that the
metabolic hormone FGF21 is regulated by endoplasmic reticulum (ER) stress, a condition
that is observed in a number of diseases including NAFLD and results in activation of an
adaptive response known as the unfolded protein response (UPR). ER stress stimuli were …