[HTML][HTML] The transcription factor network associated with the amino acid response in mammalian cells
MS Kilberg, M Balasubramanian, L Fu, J Shan - Advances in nutrition, 2012 - Elsevier
Mammals exhibit multiple adaptive mechanisms that sense and respond to fluctuations in
dietary nutrients. Consumption of reduced total dietary protein or a protein diet that is
deficient in 1 or more of the essential amino acids triggers wide-ranging changes in feeding
behavior and gene expression. At the level of individual cells, dietary protein deficiency is
manifested as amino acid (AA) deprivation, which activates the AA response (AAR). The
AAR is composed of a collection of signal transduction pathways that terminate in specific …
dietary nutrients. Consumption of reduced total dietary protein or a protein diet that is
deficient in 1 or more of the essential amino acids triggers wide-ranging changes in feeding
behavior and gene expression. At the level of individual cells, dietary protein deficiency is
manifested as amino acid (AA) deprivation, which activates the AA response (AAR). The
AAR is composed of a collection of signal transduction pathways that terminate in specific …