Novel role for mast cells in omental tissue remodeling and cell recruitment in experimental peritoneal dialysis

M Zareie, P Fabbrini, LHP Hekking… - Journal of the …, 2006 - journals.lww.com
Because of its dynamic structure, the omentum plays a key role in the immunity of the
peritoneal cavity by orchestrating peritoneal cell recruitment. Because mast cells accumulate
in the omentum upon experimental peritoneal dialysis (PD) and may produce
angiogenic/profibrotic factors, it was hypothesized that mast cells mediate omental tissue
remodeling during PD. Daily treatment with conventional PD fluid (PDF) for 5 wk resulted in
a strong omental remodeling response, characterized by an approximately 10-fold increase …