Chenodeoxycholate Is an Inhibitor of Clostridium difficile Spore Germination
JA Sorg, AL Sonenshein - Journal of bacteriology, 2009 - Am Soc Microbiol
JA Sorg, AL Sonenshein
Journal of bacteriology, 2009•Am Soc MicrobiolSome cholate derivatives that are normal components of bile can act with glycine to induce
the germination of Clostridium difficile spores, but at least one bile component,
chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate
inhibits the germination of C. difficile spores in response to cholate and taurocholate.
the germination of Clostridium difficile spores, but at least one bile component,
chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate
inhibits the germination of C. difficile spores in response to cholate and taurocholate.
Abstract
Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.
American Society for Microbiology