Lack of association of tcdC type and binary toxin status with disease severity and outcome in toxigenic Clostridium difficile
SD Goldenberg, GL French - Journal of infection, 2011 - Elsevier
The production of binary toxin and presence of truncating mutations in the putative toxin
repressor gene, tcdC, have been associated with the increased virulence and spread of
Clostridium difficile, especially ribotype 027. We analysed the prevalence of binary toxin
genes and tcdC mutations in 207 clinical C. difficile isolates collected between 2008–2010.
The majority (83%) belonged to one of five tcdC types and 8% were ribotype 027. There was
little evidence of epidemic spread but there was a high prevalence of both predicted tcdC …
repressor gene, tcdC, have been associated with the increased virulence and spread of
Clostridium difficile, especially ribotype 027. We analysed the prevalence of binary toxin
genes and tcdC mutations in 207 clinical C. difficile isolates collected between 2008–2010.
The majority (83%) belonged to one of five tcdC types and 8% were ribotype 027. There was
little evidence of epidemic spread but there was a high prevalence of both predicted tcdC …