Interruption of recurrent Clostridium difficile-associated diarrhea episodes by serial therapy with vancomycin and rifaximin
S Johnson, C Schriever, M Galang… - Clinical Infectious …, 2007 - academic.oup.com
S Johnson, C Schriever, M Galang, CP Kelly, DN Gerding
Clinical Infectious Diseases, 2007•academic.oup.comEight women who each experienced 4–8 episodes of Clostridium difficile–associated
diarrhea were given a 2-week course of rifaximin therapy when they were asymptomatic,
immediately after completing their last course of vancomycin therapy. Seven of the 8 patients
experienced no further diarrhea recurrence. The patient who had a recurrence responded to
a second course of rifaximin therapy, but rifaximin-resistant C. difficile was recovered after
treatment. A controlled trial for treating recurrent Clostridium difficile–associated diarrhea …
diarrhea were given a 2-week course of rifaximin therapy when they were asymptomatic,
immediately after completing their last course of vancomycin therapy. Seven of the 8 patients
experienced no further diarrhea recurrence. The patient who had a recurrence responded to
a second course of rifaximin therapy, but rifaximin-resistant C. difficile was recovered after
treatment. A controlled trial for treating recurrent Clostridium difficile–associated diarrhea …
Abstract
Eight women who each experienced 4–8 episodes of Clostridium difficile–associated diarrhea were given a 2-week course of rifaximin therapy when they were asymptomatic, immediately after completing their last course of vancomycin therapy. Seven of the 8 patients experienced no further diarrhea recurrence. The patient who had a recurrence responded to a second course of rifaximin therapy, but rifaximin-resistant C. difficile was recovered after treatment. A controlled trial for treating recurrent Clostridium difficile–associated diarrhea appears to be warranted.
Oxford University Press