Tolevamer Is Not Efficacious in the Neutralization of Cytotoxin in a Human Gut Model of Clostridium difficile Infection
SD Baines, J Freeman, MH Wilcox - Antimicrobial agents and …, 2009 - Am Soc Microbiol
SD Baines, J Freeman, MH Wilcox
Antimicrobial agents and chemotherapy, 2009•Am Soc MicrobiolThe efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in
treating simulated Clostridium difficile infection in an in vitro human gut model was
investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by
C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.
treating simulated Clostridium difficile infection in an in vitro human gut model was
investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by
C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.
Abstract
The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.
American Society for Microbiology