Localization of a Breast Cancer Susceptibility Gene, BRCA2, to Chromosome 13q12-13
R Wooster, SL Neuhausen, J Mangion, Y Quirk, D Ford… - Science, 1994 - science.org
R Wooster, SL Neuhausen, J Mangion, Y Quirk, D Ford, N Collins, K Nguyen, S Seal, T Tran…
Science, 1994•science.orgA small proportion of breast cancer, in particular those cases arising at a young age, is due
to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A
genomic linkage search was performed with 15 high-risk breast cancer families that were
unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second
breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome
13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer …
to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A
genomic linkage search was performed with 15 high-risk breast cancer families that were
unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second
breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome
13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer …
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.
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