The SDF-1/CXCL 12/CXCR4 biological axis in non-small cell lung cancer metastases
JA Belperio, RJ Phillips, MD Burdick, M Lutz, M Keane… - Chest, 2004 - journal.chestnet.org
Non-small cell lung cancer (NSCLC) is characterized by a specific metastatic pattern. The
mechanism for organ-specific metastasis is poorly understood, although recent evidence
has suggested that the chemokine stromal derived factor-1 (CXCL12) and its cognate
receptor CXCR4 may regulate breast cancer metastasis. We hypothesized that the
CXCL12/CXCR4 biological axis is important in mediating NSCLC metastases. Our results
indicate that both NSCLC tumor specimens resected from patients and NSCLC cell lines …
mechanism for organ-specific metastasis is poorly understood, although recent evidence
has suggested that the chemokine stromal derived factor-1 (CXCL12) and its cognate
receptor CXCR4 may regulate breast cancer metastasis. We hypothesized that the
CXCL12/CXCR4 biological axis is important in mediating NSCLC metastases. Our results
indicate that both NSCLC tumor specimens resected from patients and NSCLC cell lines …