Patients with alcoholism exhibit behavioral adaptations to ethanol such as tolerance,
dependence, and addiction. Molecular mechanisms that underlie these altered behavioral
responses to ethanol are largely unclear. We have performed oligonucleotide microarray
analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes
represented on microarray, a total of 79 genes showed differential expression changes in
alcoholics compared with control subjects, consisting of 54 up-and 25 down-regulated …