TNF-α-dependent regulation of CXCR3 expression modulates neuronal survival during West Nile virus encephalitis
B Zhang, J Patel, M Croyle, MS Diamond… - Journal of …, 2010 - Elsevier
The chemokine CXCL10 exerts antiviral effects within the central nervous system (CNS)
through the recruitment of virus-specific T cells. However, elevated levels of CXCL10 may
induce neuronal apoptosis given its receptor, CXCR3, is expressed by neurons. Using a
murine model of West Nile virus (WNV) encephalitis, we determined that WNV-infected
neurons express TNF-α, which down-regulates neuronal CXCR3 expression via signaling
through TNFR1. Down-regulation of neuronal CXCR3 decreased CXCL10-mediated …
through the recruitment of virus-specific T cells. However, elevated levels of CXCL10 may
induce neuronal apoptosis given its receptor, CXCR3, is expressed by neurons. Using a
murine model of West Nile virus (WNV) encephalitis, we determined that WNV-infected
neurons express TNF-α, which down-regulates neuronal CXCR3 expression via signaling
through TNFR1. Down-regulation of neuronal CXCR3 decreased CXCL10-mediated …