[HTML][HTML] Roles of heat shock protein gp96 in the ER quality control: redundant or unique function?
Y Yang, Z Li - Molecules and cells, 2005 - Elsevier
Heat shock protein gp96 is an endoplasmic reticulum chaperone, belonging to the HSP90
family. The function of gp96 as a molecular chaperone was discovered more than 10 years
ago, but its importance has been overshadowed by the brilliance of its role in immune
responses. It is now clear that gp96 is instrumental in the initiation of both the innate and
adaptive immunity. Recently, the roles of gp96 in protein homeostasis, as well as in cell
differentiation and development, are beginning to draw more attention due to rapid …
family. The function of gp96 as a molecular chaperone was discovered more than 10 years
ago, but its importance has been overshadowed by the brilliance of its role in immune
responses. It is now clear that gp96 is instrumental in the initiation of both the innate and
adaptive immunity. Recently, the roles of gp96 in protein homeostasis, as well as in cell
differentiation and development, are beginning to draw more attention due to rapid …