[HTML][HTML] Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress
Q Sun, W Gao, P Loughran, R Shapiro, J Fan… - Journal of Biological …, 2013 - ASBMB
Caspase 1 activation can be induced by oxidative stress, which leads to the release of the
proinflammatory cytokines IL1β and IL18 in myeloid cells and a potentially damaging
inflammatory response. However, little is known about the role of caspase 1 in non-immune
cells, such as hepatocytes, that express and activate the inflammasome but do not produce
a significant amount of IL1β/IL18. Here we demonstrate that caspase 1 activation protects
against cell death after redox stress induced by hypoxia/reoxygenation in hepatocytes …
proinflammatory cytokines IL1β and IL18 in myeloid cells and a potentially damaging
inflammatory response. However, little is known about the role of caspase 1 in non-immune
cells, such as hepatocytes, that express and activate the inflammasome but do not produce
a significant amount of IL1β/IL18. Here we demonstrate that caspase 1 activation protects
against cell death after redox stress induced by hypoxia/reoxygenation in hepatocytes …