Characterization of the proteome, diseases and evolution of the human postsynaptic density
À Bayés, LN Van De Lagemaat, MO Collins… - Nature …, 2011 - nature.com
Nature neuroscience, 2011•nature.com
We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461
proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were
enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong
protein sequence conservation in mammalian lineages, particularly in hub proteins,
indicates conserved function and organization in primate and rodent models. The hPSD is
an important structure for nervous system disease and behavior.
proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were
enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong
protein sequence conservation in mammalian lineages, particularly in hub proteins,
indicates conserved function and organization in primate and rodent models. The hPSD is
an important structure for nervous system disease and behavior.
Abstract
We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461 proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation in mammalian lineages, particularly in hub proteins, indicates conserved function and organization in primate and rodent models. The hPSD is an important structure for nervous system disease and behavior.
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