Intracranial hemorrhage in alloimmune thrombocytopenia: stratified management to prevent recurrence in the subsequent affected fetus
JB Bussel, RL Berkowitz, C Hung, EA Kolb… - American journal of …, 2010 - Elsevier
OBJECTIVE: We sought to prevent intracranial hemorrhage (ICH) through antenatal
management of alloimmune thrombocytopenia. STUDY DESIGN: A total of 33 women (37
pregnancies) with alloimmune thrombocytopenia and ICH in a previous child were stratified
according to the timing of the previous child's ICH: extremely high risk (HR)(n= 8) had ICH<
28 weeks, very HR (n= 17) between 28-36 weeks, and HR (n= 12) in the perinatal period.
Treatment was initiated at 12 weeks with intravenous immunoglobulin 1 or 2 g/kg/wk, and if …
management of alloimmune thrombocytopenia. STUDY DESIGN: A total of 33 women (37
pregnancies) with alloimmune thrombocytopenia and ICH in a previous child were stratified
according to the timing of the previous child's ICH: extremely high risk (HR)(n= 8) had ICH<
28 weeks, very HR (n= 17) between 28-36 weeks, and HR (n= 12) in the perinatal period.
Treatment was initiated at 12 weeks with intravenous immunoglobulin 1 or 2 g/kg/wk, and if …