S-Nitrosoglutathione reductase (GSNOR) is an alcohol dehydrogenase involved in the
regulation of S-nitrosothiols (SNOs) in vivo. Knock-out studies in mice have shown that
GSNOR regulates the smooth muscle tone in airways and the function of β-adrenergic
receptors in lungs and heart. GSNOR has emerged as a target for the development of
therapeutic approaches for treating lung and cardiovascular diseases. We report three
compounds that exclude GSNOR substrate, S-nitrosoglutathione (GSNO) from its binding …