NO participates in numerous biological events in a variety of cell types including activated
glomerular mesangial cells. Many of these events appear to be independent of the known
effects of NO on soluble guanylyl cyclase. NO derived from all major isoforms of NO
synthase can S-nitrosylate cysteine residues in target proteins, potentially altering their
functional activities. Recent evidence suggests that S-nitrosylation is specific, is regulated,
and may play an important regulatory role akin to phosphorylation. In the present study, the" …