Bone morphogenetic proteins in development

BLM Hogan - Current opinion in genetics & development, 1996 - Elsevier
Current opinion in genetics & development, 1996Elsevier
The bone morphogenetic proteins (BMPs) constitute a large family of cytokines related to
members of the transforming growth factor-β superfamily. Recent evidence, in particular from
gene targeting experiments in the mouse, indicates that BMPs are required for mesoderm
formation and for the development and patterning of many different organ systems.
Significant progress has also been made in understanding the role of BMPs in gastrulation
and neurulation in Xenopus and in identifying genes regulating BMP expression and …
The bone morphogenetic proteins (BMPs) constitute a large family of cytokines related to members of the transforming growth factor-β superfamily. Recent evidence, in particular from gene targeting experiments in the mouse, indicates that BMPs are required for mesoderm formation and for the development and patterning of many different organ systems. Significant progress has also been made in understanding the role of BMPs in gastrulation and neurulation in Xenopus and in identifying genes regulating BMP expression and components of the downstream signaling pathways. Extracellular modifiers of BMP activity may constitute an opposing morphogenetic system.
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