Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials

J Koreth, R Schlenk, KJ Kopecky, S Honda, J Sierra… - Jama, 2009 - jamanetwork.com
Context The optimal treatment of acute myeloid leukemia (AML) in first complete remission
(CR1) is uncertain. Current consensus, based on cytogenetic risk, recommends
myeloablative allogeneic stem cell transplantation (SCT) for poor-risk but not for good-risk
AML. Allogeneic SCT, autologous transplantation, and consolidation chemotherapy are
considered of equivalent benefit for intermediate-risk AML. Objective To quantify relapse-
free survival (RFS) and overall survival benefit of allogeneic SCT for AML in CR1 overall and …