[HTML][HTML] Molecular mechanisms of cellular cholesterol efflux
MC Phillips - Journal of Biological Chemistry, 2014 - ASBMB
Most types of cells in the body do not express the capability of catabolizing cholesterol, so
cholesterol efflux is essential for homeostasis. For instance, macrophages possess four
pathways for exporting free (unesterified) cholesterol to extracellular high density lipoprotein
(HDL). The passive processes include simple diffusion via the aqueous phase and
facilitated diffusion mediated by scavenger receptor class B, type 1 (SR-BI). Active pathways
are mediated by the ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, which …
cholesterol efflux is essential for homeostasis. For instance, macrophages possess four
pathways for exporting free (unesterified) cholesterol to extracellular high density lipoprotein
(HDL). The passive processes include simple diffusion via the aqueous phase and
facilitated diffusion mediated by scavenger receptor class B, type 1 (SR-BI). Active pathways
are mediated by the ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, which …