[PDF][PDF] Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types
CJ Taylor, S Peacock, AN Chaudhry, JA Bradley… - Cell stem cell, 2012 - cell.com
CJ Taylor, S Peacock, AN Chaudhry, JA Bradley, EM Bolton
Cell stem cell, 2012•cell.comThe likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched
induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a
tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the
UK population with a minimal requirement for immunosuppression. Our model provides a
practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank
that circumvents prospective typing of a large number of individuals.
induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a
tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the
UK population with a minimal requirement for immunosuppression. Our model provides a
practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank
that circumvents prospective typing of a large number of individuals.
The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.
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