MicroRNA-132 is frequently down-regulated in ductal carcinoma in situ (DCIS) of breast and acts as a tumor suppressor by inhibiting cell proliferation
S Li, H Meng, F Zhou, L Zhai, L Zhang, F Gu… - … -Research and Practice, 2013 - Elsevier
Ductal carcinoma in situ (DCIS) is the most common type of non-invasive breast cancer. The
currently accepted step-wise model suggests that breast cancer progressed in the following
manner: normal breast cell→ usually ductal hyperplasia (UDH)→ atypical ductal hyperplasia
(ADH)→ DCIS→ invasive ductal carcinoma (IDC). Therefore, DCIS can serve as a good
model to analyze the mechanism underlying invasive breast cancer occurrence. MicroRNAs
(miRNAs) are a novel class of small non-coding RNAs (∼ 22nt) involved in the regulation of …
currently accepted step-wise model suggests that breast cancer progressed in the following
manner: normal breast cell→ usually ductal hyperplasia (UDH)→ atypical ductal hyperplasia
(ADH)→ DCIS→ invasive ductal carcinoma (IDC). Therefore, DCIS can serve as a good
model to analyze the mechanism underlying invasive breast cancer occurrence. MicroRNAs
(miRNAs) are a novel class of small non-coding RNAs (∼ 22nt) involved in the regulation of …