[HTML][HTML] Impaired cardiac performance in heterozygous mice with a null mutation in the sarco (endo) plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene

M Periasamy, TD Reed, LH Liu, Y Ji… - Journal of Biological …, 1999 - ASBMB
The sarco (endo) plasmic reticulum Ca 2+-ATPase isoform 2 (SERCA2) gene encodes both
SERCA2a, the cardiac sarcoplasmic reticulum Ca 2+ pump, and SERCA2b, which is
expressed in all tissues. To gain a better understanding of the physiological functions of
SERCA2, we used gene targeting to develop a mouse in which the promoter and 5′ end of
the gene were eliminated. Mating of heterozygous mutant mice yielded wild-type and
heterozygous offspring; homozygous mutants were not observed. RNase protection …