Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development
C Garcia-Frigola, Y Shi, SM Evans - Gene Expression Patterns, 2003 - Elsevier
HCN4 is a hyperpolarization-activated nucleotide-gated cation channel involved in the
generation of the If current that drives cardiac pacemaker activity. Previous studies have
demonstrated that HCN4 is highly expressed in a restricted manner in adult sinoatrial (SA)
node [Eur. J. Biochem. 268 (2001) 1646]. However, its developmental expression pattern is
unknown. We have examined expression of HCN4 mRNA during mouse heart development.
HCN4 mRNA was first detected in the cardiac crescent at embryonic day (ED) 7.5. At ED 8 it …
generation of the If current that drives cardiac pacemaker activity. Previous studies have
demonstrated that HCN4 is highly expressed in a restricted manner in adult sinoatrial (SA)
node [Eur. J. Biochem. 268 (2001) 1646]. However, its developmental expression pattern is
unknown. We have examined expression of HCN4 mRNA during mouse heart development.
HCN4 mRNA was first detected in the cardiac crescent at embryonic day (ED) 7.5. At ED 8 it …