Purinergic P2Y2 receptors mediate rapid Ca2+ mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells
A Raqeeb, J Sheng, N Ao, AP Braun - Cell calcium, 2011 - Elsevier
In blood vessels, stimulation of the vascular endothelium by the Ca2+-mobilizing agonist
ATP initiates a number of cellular events that cause relaxation of the adjacent smooth
muscle layer. Although vascular endothelial cells are reported to express several subtypes
of purinergic P2Y and P2X receptors, the major isoform (s) responsible for the ATP-induced
generation of vasorelaxant signals in human endothelium has not been well characterized.
To address this issue, ATP-evoked changes in cytosolic Ca2+, membrane potential and …
ATP initiates a number of cellular events that cause relaxation of the adjacent smooth
muscle layer. Although vascular endothelial cells are reported to express several subtypes
of purinergic P2Y and P2X receptors, the major isoform (s) responsible for the ATP-induced
generation of vasorelaxant signals in human endothelium has not been well characterized.
To address this issue, ATP-evoked changes in cytosolic Ca2+, membrane potential and …