Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapy

J Zhou, ME Dudley, SA Rosenberg… - Journal of …, 2005 - journals.lww.com
The authors recently reported that adoptive immunotherapy with autologous tumor-reactive
tumor infiltrating lymphocytes (TILs) immediately following a conditioning nonmyeloablative
chemotherapy regimen resulted in an enhanced clinical response rate in patients with
metastatic melanoma. These observations led to the current studies, which are focused on a
detailed analysis of the T-cell antigen reactivity as well as the in vivo persistence of T cells in
melanoma patient 2098, who experienced a complete regression of all metastatic lesions in …