[HTML][HTML] Smooth and cardiac muscle-selective knock-out of Krüppel-like factor 4 causes postnatal death and growth retardation

T Yoshida, Q Gan, AS Franke, R Ho, J Zhang… - Journal of biological …, 2010 - ASBMB
Krüppel-like factor 4 (Klf4) is a transcription factor involved in differentiation and proliferation
in multiple tissues. We demonstrated previously that tamoxifen-induced deletion of the Klf4
gene in mice accelerated neointimal formation but delayed down-regulation of smooth
muscle cell differentiation markers in carotid arteries following injury. To further determine
the role of Klf4 in the cardiovascular system, we herein derived mice deficient for the Klf4
gene in smooth and cardiac muscle using the SM22α promoter (SM22α-CreKI+/Klf4 …