Human neoplasms elicit multiple specific immune responses in the autologous host.

U Sahin, O Türeci, H Schmitt… - Proceedings of the …, 1995 - National Acad Sciences
U Sahin, O Türeci, H Schmitt, B Cochlovius, T Johannes, R Schmits, F Stenner, G Luo…
Proceedings of the national academy of sciences, 1995National Acad Sciences
Expression of cDNA libraries from human melanoma, renal cancer, astrocytoma, and
Hodgkin disease in Escherichia coli and screening for clones reactive with high-titer IgG
antibodies in autologous patient serum lead to the discovery of at least four antigens with a
restricted expression pattern in each tumor. Besides antigens known to elicit T-cell
responses, such as MAGE-1 and tyrosinase, numerous additional antigens that were
overexpressed or specifically expressed in tumors of the same type were identified …
Expression of cDNA libraries from human melanoma, renal cancer, astrocytoma, and Hodgkin disease in Escherichia coli and screening for clones reactive with high-titer IgG antibodies in autologous patient serum lead to the discovery of at least four antigens with a restricted expression pattern in each tumor. Besides antigens known to elicit T-cell responses, such as MAGE-1 and tyrosinase, numerous additional antigens that were overexpressed or specifically expressed in tumors of the same type were identified. Sequence analyses suggest that many of these molecules, besides being the target of a specific immune response, might be of relevance for tumor growth. Antibodies to a given antigen were usually confined to patients with the same tumor type. The unexpected frequency of human tumor antigens, which can be readily defined at the molecular level by the serological analysis of autologous tumor cDNA expression cloning, indicates that human neoplasms elicit multiple specific immune responses in the autologous host and provides diagnostic and therapeutic approaches to human cancer.
National Acad Sciences