The validity of predicted T-cell epitopes

C Lundegaard, M Nielsen, O Lund - Trends in biotechnology, 2006 - cell.com
Trends in biotechnology, 2006cell.com
High-performing MHC class I binding predictions have been available for more than a
decade; however, their value in terms of actual epitope finding has only now been estimated
in a large-scale investigation undertaken by the group of Sette. This work underlines the
importance of bioinformatics as a resource-saving tool in the field of epitope discovery. In
addition, the data can be used to benchmark the performance of other new or existing CTL
epitope-prediction tools.
High-performing MHC class I binding predictions have been available for more than a decade; however, their value in terms of actual epitope finding has only now been estimated in a large-scale investigation undertaken by the group of Sette. This work underlines the importance of bioinformatics as a resource-saving tool in the field of epitope discovery. In addition, the data can be used to benchmark the performance of other new or existing CTL epitope-prediction tools.
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