[HTML][HTML] Hypoxic signaling during tissue repair and regenerative medicine

TD Nauta, VWM Van Hinsbergh, P Koolwijk - International journal of …, 2014 - mdpi.com
TD Nauta, VWM Van Hinsbergh, P Koolwijk
International journal of molecular sciences, 2014mdpi.com
In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the
wound. These patients might benefit from regenerative medicine or the implantation of a
tissue-engineered scaffold. Both wound healing and tissue engineering is dependent on the
formation of a microvascular network. This process is highly regulated by hypoxia and the
transcription factors hypoxia-inducible factors-1α (HIF-1α) and-2α (HIF-2α). Even though
much is known about the function of HIF-1α in wound healing, knowledge about the function …
In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the wound. These patients might benefit from regenerative medicine or the implantation of a tissue-engineered scaffold. Both wound healing and tissue engineering is dependent on the formation of a microvascular network. This process is highly regulated by hypoxia and the transcription factors hypoxia-inducible factors-1α (HIF-1α) and -2α (HIF-2α). Even though much is known about the function of HIF-1α in wound healing, knowledge about the function of HIF-2α in wound healing is lacking. This review focuses on the function of HIF-1α and HIF-2α in microvascular network formation, wound healing, and therapy strategies.
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