[HTML][HTML] ApoA-IMilano/Phospholipid Complex: Clinical Implications of Dose-Response Studies in Rabbit Atherosclerosis With Intravascular Ultrasound and Magnetic …

XQ Zhao, BG Brown - Journal of the American College of Cardiology, 2008 - jacc.org
XQ Zhao, BG Brown
Journal of the American College of Cardiology, 2008jacc.org
Parolini et al.(1) report in this issue of the Journal on the effects of recombinant apoA-
IMilano/1-palmitoyl-2-oleoyl phosphatidylcholine complexes (ETC-216) on injuryinduced
carotid atherosclerotic plaques in cholesterol-fed New Zealand White rabbits (2). The rabbits
received 1 of 5 different intravenous doses (5, 10, 20, 40, or 150 mg/kg) of ETC-216 or
placebo every 4 days for 5 infusions. Intravascular ultrasound was used to measure carotid
atheroma volume at baseline and after the final infusion. Contrastenhanced magnetic …
Parolini et al.(1) report in this issue of the Journal on the effects of recombinant apoA-IMilano/1-palmitoyl-2-oleoyl phosphatidylcholine complexes (ETC-216) on injuryinduced carotid atherosclerotic plaques in cholesterol-fed New Zealand White rabbits (2). The rabbits received 1 of 5 different intravenous doses (5, 10, 20, 40, or 150 mg/kg) of ETC-216 or placebo every 4 days for 5 infusions. Intravascular ultrasound was used to measure carotid atheroma volume at baseline and after the final infusion. Contrastenhanced magnetic resonance imaging (MRI) was performed before treatment and after infusion of the second and fifth dose of placebo, 40 or 150 mg/kg.
jacc.org